Correlation of Serum Creatinine with TSH in Overt Hypothyroidism Patients

In this study, we aim to determine the correlation between serum creatinine and TSH values in overt hypothyroidism patients. This cross - sectional descriptive study was conducted from October 2022 to April 2024 in the Department of General Medicine and Endocrinology at Justice K. S Hegde Charitable Hospital, a constituent unit of Nitte (Deemed to be University). A total of 62 hypothyroid patients were selected using convenience sampling. Clinical data, including serum TSH, creatinine was collected along with patient demographics and medical histories. Statistical analysis was performed using SPSS version26.0, employing descriptive statistics, spearman correlation coefficients and Mann - Whitney tests. The study included 62 patients (females 82.3%, males 17.7%) with a mean age of 43.56 years. The mean TSH, creatinine of the patients in the present study were 19.05 uIU/ml, 0.87 mg/dl. There was no significant correlation between TSH and creatinine. We conclude that among the overt hypothyroidism patients, TSH was positively correlated with creatinine. However, the differentials were not statistically significant. We recommend conducting further studies to estimate the effect of various thyroid factors on kidney function tests and the long - term impact of hypothyroidism treatment on kidney health.