IMMUNOSTIMULATORY EFFECT OF JASMINUM SUBTRIPLINERVE BLUME LEAVES EXTRACT ON CYCLOPHOSPHAMIDE-INDUCED IMMUNOSUPPRESSION IN MICE
The objective of this study was to evaluate the immunostimulatory activity of Jasminum subtriplinerve Blume. extract (JM). We induced the immunosuppression in Swiss mice by cyclophosphamide (CP). Jasminum subtriplinerve Blume. extract 14.4 g/kg body weight was administered orally 7 consecutive days to animals and CP (200 mg/kg i.p.) was injected on 4th day. The result showed that Jasminum subtriplinerve Blume. leaves extract 14.4 g/kg ameliorated the effects of CP on delayed type hypersensitivity (DTH) response, leukocyte quantity, relative organ weight, IgM concentration and micro-histological images. This suggested the potential of Jasminum subtriplinerve Blume leaves extract to treat immunosuppression diseases in clinical practice.
Authors
- Thanh Tung Bui
- Hồng Minh Phan
- Thai Tran (ORCID: https://orcid.org/0000-0002-8662-3676)
- Xuân Hồng Nguyễn
- Thi Van Anh Pham (ORCID: https://orcid.org/0000-0002-1782-348X)
- Thi Thu Trang Tran
- Phuong Nguyen Thanh (ORCID: https://orcid.org/0000-0001-5867-6888)
- My Dung Ho
Institutions
- Vietnam National University, Hanoi (VN)
- Hanoi Medical University (VN)
- Hanoi University of Pharmacy (VN)
Publication Details
- Journal
- Tạp chí Y học Việt Nam
- Published
- 2024-11-29
- DOI
- https://doi.org/10.51298/vmj.v544i2.11908
- Primary Topic
- Nigella sativa pharmacological applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tập đoàn Vingroup - Công ty CP
- Quỹ Đổi mới sáng tạo Vingroup