Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice
These findings unveil novel mechanistic insights into MASH pathogenesis, suggesting targeting macrophage-specific DHCR7 activation may offer a promising therapeutic strategy for MASH.
Authors
- Jiaxuan Wu
- Yanqi Dang (ORCID: https://orcid.org/0000-0002-0316-7880)
- Yunhong Sun
- X. Li
- Kai You Wang (ORCID: https://orcid.org/0000-0002-6170-4744)
- Meng Li (ORCID: https://orcid.org/0000-0002-3602-3429)
- Yirong Wang (ORCID: https://orcid.org/0000-0002-1445-472X)
- Wenjun Zhou (ORCID: https://orcid.org/0009-0009-1865-7514)
Institutions
- Shanghai Innovative Research Center of Traditional Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s12967-024-05905-1
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China