10009- COT-3 IMPACT OF LIVING CIRCUMSTANCES OF THE OLD GLIOMA PATIENTS ON EARLY INTERVENTION

Abstract AIM Glioma is a growing malignant brain tumor, so early diagnosis and early treatment are important. The declining KPS due to symptom progression is associated with the declining postoperative KPS and tumor resection rate, shortened patient survival. The associating between social connections and medical treatment in elderly glioma patients is unclear. To determine whether social connections around the senior patient associate the decreasing postoperative KPS. METHODS We have studied 121 patients with glioma operative at the Kochi University Hospital from 2013 to 2022. Preoperative KPS decline outcome was defined as KPS<80. Patients’ social connections with their surroundings were classified into three groups based on record information: “living alone,” “senior couple,” and “with children’s involvement. “First, the patients were classified into a younger group under 60 years old (40 patients) and an elderly group over 60 years old (81 patients), and the preoperative KPS was compared between the two groups. Second, we examined whether social connections associated declining preoperative KPS in the elderly subgroup. RESULTS In the elderly group, the proportion of patients with declining preoperative KPS was 29/81, which was significantly higher than the proportion in the younger group (6/40) (P=0.031, chi-square test). In the elderly group, the rate of declining preoperative KPS according to social connections was lower in those with “ with children’s involvement “ (2/14) compared to those who “lived alone” (8/19) and those who “ senior couple “ (19/48), indicating that child involvement was associated with higher preoperative KPS in elderly patients with glioma. CONCLUSION Glioma patients over 60 years of age are at risk of declining preoperative KPS, especially in the setting of low children’s involvement. As the population continues to age, it will be necessary to consider the social connections between glioma patients and those around them and encourage early hospital visit.