Gremlin-2 is a novel tumor suppressor that negatively regulates ID1 in breast cancer
Low expression of GREM2 in breast cancer cells is associated with hypermethylation of the GREM2 promoter, which may ultimately contribute to poor patient survival. GREM2 participates in regulating the expression of various genes, including ID1, and is involved in suppressing the proliferation of breast cancer cells. This suggests that GREM2 has the potential to act as a novel tumor suppressor in breast cancer.
Authors
- Jiwoo Jung
- Mee‐Hyun Lee (ORCID: https://orcid.org/0000-0002-1216-0218)
- Sin‐Aye Park (ORCID: https://orcid.org/0000-0003-2456-3572)
- Yong-Bin Eom
- Jayeon Park (ORCID: https://orcid.org/0000-0001-5085-8281)
- Minji Kwon (ORCID: https://orcid.org/0000-0002-5024-7664)
- Suyeon Jung
- Dayeon Lim
- Na Hui Kim
- Ye Hwang Cheong
- Hee Sun Park
- World Gil
- Minjeong Go
- C. Kim
Institutions
- Dongshin University (KR)
- Chungnam National University (KR)
- Soonchunhyang University (KR)
- Dong-A Pharmaceutical (South Korea) (KR)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s13058-024-01935-1
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- National Research Foundation
- Soonchunhyang University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea