Differential effects of thiamine and ascorbic acid in clusters of septic patients identified by latent variable analysis
These results reinforce the lack of efficacy of the combination of AA + B1 reported in recent trials and even raise concerns about potential harm in older patients with comorbidities. On the contrary, we reported improved ICU survival associated with B1 supplementation in the most severe patients and those with predominant respiratory failure, supporting the need for further trials in this specific population.
Authors
- Hervé Quintard (ORCID: https://orcid.org/0000-0002-3870-6370)
- Sebastian Sgardello (ORCID: https://orcid.org/0000-0002-0559-4667)
- Frederic Sangla
- Antoine Schneider (ORCID: https://orcid.org/0000-0003-0576-7094)
- Gilles Criton
- Céline Monard (ORCID: https://orcid.org/0000-0003-2240-0905)
- David Legouis (ORCID: https://orcid.org/0000-0002-2924-9737)
- Aimad Ourahmoune (ORCID: https://orcid.org/0000-0002-8884-4034)
Institutions
- University of Geneva (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- University Hospital of Geneva (CH)
- Centre universitaire de médecine générale et santé publique, Lausanne (CH)
- Hôpital du Valais (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Critical Care
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s13054-024-05188-4
- Citations
- 1
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- Hôpitaux Universitaires de Genève
- Université de Genève
- Fondation Ernst et Lucie Schmidheiny