The Influence of MAOA Gene variants and hormonal regulation on aggression and psychiatric vulnerabilities

This review explores the connection between genetic factors and psychiatric disorders, emphasizing the role of the MAOA gene, cortisol, testosterone, and their interaction with environmental influences. Specifically, it investigates how the MAOA gene and hormone levels contribute to behavioral tendencies, such as aggression and impulsivity, by affecting the prefrontal cortex, amygdala, and limbic system. The study also considers how genetic predispositions are intensified by external stressors like trauma, highlighting the gene-environment interaction’s significance in developing conditions like schizophrenia, bipolar disorder, and depression. Ultimately, the research aims to clarify the neurobiological mechanisms underlying these disorders, suggesting that integrating genetic and environmental factors could guide personalized treatments.