The microneme protein1 (MIC1) of Chinese 1 Toxoplasma regulates pyroptosis through the TLR4/NLRP3 pathway in macrophages
TgMIC1 is implicated in both parasite invasion and the modulation of macrophage pyroptosis via the TLR4/NLRP3 pathway. This investigation indicates that TgMIC1 serves diverse functions in Toxoplasma gondii infection, thereby enhancing comprehension of the immune regulatory mechanisms of the parasite.
Authors
- Li Yu
- Fan Zhang (ORCID: https://orcid.org/0000-0003-4623-4200)
- Yang Wang (ORCID: https://orcid.org/0000-0001-6007-8828)
- Jinjin Zhu (ORCID: https://orcid.org/0000-0002-3951-8670)
- Wenze Sun
- Yanxia Yu (ORCID: https://orcid.org/0009-0000-9752-2806)
- Qingli Luo (ORCID: https://orcid.org/0000-0001-6173-353X)
Institutions
- Anhui Medical University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s13071-024-06584-z
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Capital Medical University
- Beijing Friendship Hospital, Capital Medical University