Recurrent Jaundice Unraveled: A Case of Benign Recurrent Intrahepatic Cholestasis (BRIC) in an Indian Patient

Benign recurrent intrahepatic cholestasis (BRIC) is a rare, autosomal recessive liver disorder characterized by intermittent episodes of cholestasis without progression to chronic liver disease or cirrhosis. Patients experience recurrent jaundice and severe pruritus, significantly impacting their quality of life. This case report presents a 15-year-old boy with a history of recurrent jaundice and pruritus. The patient was successfully managed with ursodeoxycholic acid (UDCA), leading to symptomatic relief and biochemical improvement. BRIC is a rare disorder and should be considered in the differential diagnosis of recurrent cholestasis in adolescents. Early recognition and appropriate treatment can improve patient outcomes and prevent unnecessary investigations.

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Journal
Cureus
Published
2024-11-29
DOI
https://doi.org/10.7759/cureus.74736
Primary Topic
Drug Transport and Resistance Mechanisms
Type
article
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0.00
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article

Recurrent Jaundice Unraveled: A Case of Benign Recurrent Intrahepatic Cholestasis (BRIC) in an Indian Patient

Nalini Kiran, Sonia K Saxena, Chinmaya Singh, A Patel et al.
Cureus
Drug Transport and Resistance Mechanisms
article

Recurrent Jaundice Unraveled: A Case of Benign Recurrent Intrahepatic Cholestasis (BRIC) in an Indian Patient

Nalini Kiran, Sonia K Saxena, Chinmaya Singh, A Patel, R. Bansal
article en

Abstract

Benign recurrent intrahepatic cholestasis (BRIC) is a rare, autosomal recessive liver disorder characterized by intermittent episodes of cholestasis without progression to chronic liver disease or cirrhosis. Patients experience recurrent jaundice and severe pruritus, significantly impacting their quality of life. This case report presents a 15-year-old boy with a history of recurrent jaundice and pruritus. The patient was successfully managed with ursodeoxycholic acid (UDCA), leading to symptomatic relief and biochemical improvement. BRIC is a rare disorder and should be considered in the differential diagnosis of recurrent cholestasis in adolescents. Early recognition and appropriate treatment can improve patient outcomes and prevent unnecessary investigations.

CureusVol. 16(11)
Vardhman Mahavir Medical College & Safdarjung Hospital (IN), Felix Scholarship (GB)
Zero hunger
Openalex Percentile: Top 62%
Drug Transport and Resistance Mechanisms
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Recurrent Jaundice Unraveled: A Case of Benign Recurrent Intrahepatic Cholestasis (BRIC) in an Indian Patient — Nalini Kiran, Sonia K Saxena, et al. · Cureus (2024) | TGRS Research Map | TGRS