Individual differences in prelimbic neural representation of food and cocaine seeking

The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observe prelimbic activity during both food and cocaine seeking in freely behaving mice. We find that neurobehavioral representations remain stable across days within individual mice. Unexpectedly, our data reveal significant individual differences: some mice display high similarity in their prelimbic cortex activity patterns for both food and cocaine seeking, while others show no such overlap. These findings suggest that individual differences in the neural mechanisms underlying food and cocaine seeking could be a critical factor to consider when developing future addiction treatment strategies.

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Publication Details

Journal
Cell Reports
Published
2024-11-29
DOI
https://doi.org/10.1016/j.celrep.2024.115022
Citations
9
Primary Topic
Neural dynamics and brain function
Type
article
Field-Weighted Citation Impact
3.08

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article

Individual differences in prelimbic neural representation of food and cocaine seeking

Da‐Ting Lin, Yun Li, Alexander J. Denman, Joseph T. Glanzberg et al.
9 citations
Cell Reports
Neural dynamics and brain function
3.08
article

Individual differences in prelimbic neural representation of food and cocaine seeking

Da‐Ting Lin, Yun Li, Alexander J. Denman, Joseph T. Glanzberg, Nicholas J. Beacher, Bo Liang, Yavin Shaham, Matthew C. Broomer, Giovanni Barbera, Yan Zhang
article en
9 citations

Abstract

The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observe prelimbic activity during both food and cocaine seeking in freely behaving mice. We find that neurobehavioral representations remain stable across days within individual mice. Unexpectedly, our data reveal significant individual differences: some mice display high similarity in their prelimbic cortex activity patterns for both food and cocaine seeking, while others show no such overlap. These findings suggest that individual differences in the neural mechanisms underlying food and cocaine seeking could be a critical factor to consider when developing future addiction treatment strategies.

Cell ReportsVol. 43(12)
University of Wyoming (US), National Institutes of Health (US), National Institute on Drug Abuse (US), Johns Hopkins University (US), University of North Dakota (US), National Institutes for Food and Drug Control (CN)
Howard Hughes Medical Institute, U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse
Zero hunger
Openalex Percentile: Top 8%
Neural dynamics and brain function
3.08
DOIOpen Access PDFOpenAlex
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Individual differences in prelimbic neural representation of food and cocaine seeking — Da‐Ting Lin, Yun Li, et al. · Cell Reports (2024) | TGRS Research Map | TGRS