Promoter hypermethylation-mediated downregulation of PAX6 promotes tumor growth and metastasis during the progression of liver cancer
PAX6 functions as a tumor suppressor partly through upregulation of CDH1 and downregulation of THBS1. Promoter hypermethylation-mediated suppression of PAX6 reduces the tumor suppressor function in the progression of liver cancer.
Authors
- Ya‐Wen Lin (ORCID: https://orcid.org/0000-0002-1639-7941)
- Tsai‐Yuan Hsieh (ORCID: https://orcid.org/0000-0003-4211-7015)
- Shan‐Yueh Chang (ORCID: https://orcid.org/0000-0001-8944-174X)
- Ti-Hui Wu (ORCID: https://orcid.org/0000-0002-2627-040X)
- Ching‐Hua Yeh
- Rou-Yu Chen
- Yu‐Lueng Shih (ORCID: https://orcid.org/0000-0003-4629-4393)
Institutions
- Tri-Service General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s13148-024-01789-6
- Citations
- 7
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Science Council
- Academia Sinica
- Ministry of Science and Technology, Taiwan
- Tri-Service General Hospital