Preventive effects of melatonin and amifostine on irradiated rats with experimental periodontitis
Both melatonin and amifostine can significantly limit RT-induced periodontal bone loss by suppressing inflammatory stress, apoptotic mechanisms, and RANKL-related osteoclastic activity. Given the limited side effects of melatonin, it may be an alternative to amifostine.
Authors
- Sema Yılmaz Rakıcı (ORCID: https://orcid.org/0000-0002-5543-9761)
- Oğuz Köse (ORCID: https://orcid.org/0000-0002-0318-2458)
- Adnan Yılmaz (ORCID: https://orcid.org/0000-0003-4842-1173)
- Levent Tümkaya (ORCID: https://orcid.org/0000-0001-5387-4666)
- Kerimali Akyıldız (ORCID: https://orcid.org/0000-0002-3799-7129)
- Tolga Mercantepe (ORCID: https://orcid.org/0000-0002-8506-1755)
- Nur Yorgancilar (ORCID: https://orcid.org/0009-0005-6356-7885)
Institutions
- Recep Tayyip Erdoğan University (TR)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s12903-024-05251-0
- Citations
- 5
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- Advanced Research Projects Agency