Synthesis, and Characterization of Silver Nanoparticles Functionalized with a Chalcone for Potential Antioxidant Activity

Silver nanoparticles (AgNPs) possess unusual optical, electrical, and catalytic properties. Hence, they are promising candidates in biomedical applications due to their shape and high surface area. Therefore, in present study, AgNPs were functionalized by using chalcone derivative as reducing and capping agent. The synthesized chalcone derivative was characterized by Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance (NMR), and mass spectroscopic techniques (MS). The resulting AgNPs were thoroughly characterized by different techniques, including ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS), transmission electron microscopy (TEM), and FTIR. The monodispersed AgNPs were produced with 49.5 ±6 nm diameter based on DLS results, and TEM results showed a spherical shape with a size of 30±5 nm. Also, the absorption peak at 394 nm in the UV-Vis spectrum confirmed the production of AgNPs. The biological applications of both chalcone derivative and AgNPs as antioxidant agents were evaluated. The obtained results were promising for the development of antioxidant drugs derived from silver nanoparticles functionalized chalcone derivative with hydroxy and methoxy substituents.