Accuracy of Labial Salivary Gland Biopsy in Suspected Cases of Sjogren’s Syndrome

LSGB remains a valuable diagnostic tool for SS, especially when serological and clinical findings are inconclusive. The study confirmed significant associations between ANA positivity and suggestive LSGB results, as well as the influence of other autoimmune diseases on histopathological outcomes. While Schirmer's test may detect ocular dryness, its correlation with LSGB findings was limited. LSGB should not be used as a standalone diagnostic measure but integrated with other tools, including serology and imaging, to improve accuracy. Future research should explore combining LSGB with salivary gland ultrasonography (SGUS) to enhance the detection of SS, particularly in early-stage or seronegative patients.