Clinical evaluation of advanced MALDI-TOF MS for carbapenemase subtyping in Gram-negative isolates
A-MALDI clearly demonstrated excellent ability to identify CPEs such as KPC, NDM, OXA, and GES when carbapenemase is present in the strain (100% accuracy and precision). The method also successfully discriminated carbapenemase subtypes and simultaneous detection of co-producing multiple carbapenemases in a single strain. This is the first report for simultaneous and multiple detection of intact carbapenemases of KPC, NDM, OXA, and GES using matrix-assisted laser desorption/ionization mass spectrometry in a clinical isolate.
Authors
- Dong Huey Cheon (ORCID: https://orcid.org/0000-0002-3940-3056)
- Saeyoung Lee (ORCID: https://orcid.org/0000-0001-8901-799X)
- Hee-Jung Jang
- Young Hyun Park (ORCID: https://orcid.org/0000-0003-2482-9211)
- Je‐Hyun Baek (ORCID: https://orcid.org/0000-0003-4974-8397)
- Won‐Seok Oh (ORCID: https://orcid.org/0000-0002-9247-7927)
- Ju-Ri Park
- Seohyun Hwang
- Min Jin Kim (ORCID: https://orcid.org/0000-0002-9431-1306)
- Yoon Kyung Choi (ORCID: https://orcid.org/0000-0003-0242-9612)
- Hyo-Jin Kim (ORCID: https://orcid.org/0000-0001-7191-5230)
- Sun Hwa Lee (ORCID: https://orcid.org/0000-0003-1368-1274)
- Won Suk Yang (ORCID: https://orcid.org/0000-0002-2323-6652)
Publication Details
- Journal
- Journal of Clinical Microbiology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1128/jcm.01475-24
- Citations
- 6
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 2.29