Quinoline Endoperoxides for Mitochondria Targeted Singlet Oxygen Delivery
Controlled release of singlet oxygen from chemical sources is becoming an interesting path for eliciting apoptotic death of cancer cells. In this work, we present the synthesis and characterization of hitherto unknown class of aromatic endoperoxides, namely quinoline endoperoxides. Quinolines, especially after quaternization, show significant targeting of mitochondria. This leads to more effective cytotoxicity in cancer cell cultures suggesting a potential utility in cancer therapy.
Authors
- Yang Wang (ORCID: https://orcid.org/0000-0002-4834-2128)
- Engin U. Akkaya (ORCID: https://orcid.org/0000-0003-4720-7554)
- Lei Wang (ORCID: https://orcid.org/0000-0001-6915-2713)
- Yu Si
- Xiao Qian
- Shoucai Yan
- Ziang Liu (ORCID: https://orcid.org/0000-0001-9024-7303)
- Hao Wu (ORCID: https://orcid.org/0009-0008-4813-7045)
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1002/asia.202401051
- Citations
- 1
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Natural Science Foundation of China
- Liaoning Revitalization Talents Program
- Fundamental Research Funds for the Central Universities