Electrospun ZnO and GSH Co-loaded PU/CS Nanofibrous Films as Potential Antibacterial Wound Dressings

In this paper, polyurethane nanofibers (PU)/chitosan (CS)/zinc oxide nanoparticles (ZnO)/ Glutathione (GSH) were prepared as wound dressings using the electrospinning method. First, the antibacterial effect of ZnO nanoparticles against Escherichia coli and Staphylococcus aureus was investigated. Second, the ability of the nanofibers to release different amounts of antibiotics and nanoparticles to prevent wound infection was investigated. The morphology of the composite nanofibers was investigated using field emission electron microscopy (FESEM). The chemical structure of the nano-wound dressing was examined using infrared spectroscopy (FTIR), and the FTIR spectroscopy results showed that GSH and ZnO nanoparticles were successfully arranged within the nanofibers. with an increase in the amount of GSH (1,3,5 wt%) at a constant voltage of 0.4 V, the amount of current increased by 1.7, 2.1, and 6.2 [Formula: see text]A, respectively. According to the results of electrochemical analysis, the optimal amount of active ingredient is 5 wt%, but according to the images of FESEM analysis, due to the lack of nanofibers with the corresponding morphology, the amount of active ingredient is reduced to 5 wt% PU/Chi/.