Multi-omics mechanical analysis of gut microbiota, carboxylic acids, and cardiac gene expression interaction triggering diabetic cardiomyopathy
Our research results clearly link the changes in heart genes of T2DM and normal mice with changes in serum metabolites and gut microbiota, indicating that some genes in biological processes are closely related to the reduction of protective microbiota in the gut microbiota. This study provides a theoretical basis for investigating the mechanism of DCM and may provide preliminary evidence for the future use of gut microbiota therapy for DCM.
Authors
- Hui Yuan (ORCID: https://orcid.org/0000-0001-5646-9447)
- X. Liu (ORCID: https://orcid.org/0000-0001-9241-3379)
- Wenjie Cai (ORCID: https://orcid.org/0000-0002-1505-7240)
- Can Wei (ORCID: https://orcid.org/0000-0003-4291-7653)
- Meixin Shi
- Xinyu Liu (ORCID: https://orcid.org/0000-0003-1981-148X)
- Bing Zhao (ORCID: https://orcid.org/0000-0001-5999-9240)
- Ye Jin (ORCID: https://orcid.org/0009-0003-6646-2240)
- Xiao Liang (ORCID: https://orcid.org/0000-0002-7623-3076)
- Zhitao Li
Institutions
- Harbin Medical University (CN)
- Mudanjiang Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- University Hospital of Oran (DZ)
Publication Details
- Journal
- mSystems
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1128/msystems.01450-24
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Harbin Medical University
- National Natural Science Foundation of China