Phenotypic and genomic changes in enteric <i>Klebsiella</i> populations during long-term ICU patient hospitalization: the role of RamR regulation
The <i>Klebsiella pneumoniae</i> species complex (KpSC) is one of the major causes of nosocomial infections, especially in intensive care unit (ICUs). These bacteria are frequently highly resistant to antibiotics, leading to an increase in morbidity and mortality. The origins of multidrug-resistant KpSC strains isolated from ICU patients are still unclear, with at least two hypotheses of acquisition paths: (i) endogenous KpSC populations that are or became resistant to antibiotics and/or (ii) hospital acquisition of circulating KpSC clones. Genomic changes observed in this study might reveal mechanisms to better adapt to KpSC in the patient's gut in the face of heavy ICU medical care pressure.
Authors
- Simon Le Hello (ORCID: https://orcid.org/0000-0001-7993-4305)
- Jean-Christophe Giárd (ORCID: https://orcid.org/0000-0001-8588-2732)
- Clément Gakuba (ORCID: https://orcid.org/0000-0001-6523-3954)
- Sylvain Brisse (ORCID: https://orcid.org/0000-0002-2516-2108)
- François Gravey (ORCID: https://orcid.org/0000-0001-8672-8286)
- Damien du Cheyron (ORCID: https://orcid.org/0000-0003-0833-151X)
- Bénédicte Langlois
- Christophe Isnard
Institutions
- Inserm (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Normandie Université (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Dynamique Microbienne associée aux Infections Urinaires et Respiratoires
- Université de Rouen Normandie (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- mSphere
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1128/msphere.00704-24
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.17