Mechanistic study of the regulation of mitochondrial function by the GPNMB/Nrf2/NF-κB signaling pathway mediated by Quzhi Tang to alleviate chondrocyte senescence
We concluded that the GPNMB/Nrf2/NF-κB signaling pathway plays an important role in chondrocyte senescence and that QZT was able to reduce intracellular oxidative stress and restore impaired mitochondrial function by regulating the expression level of the GPNMB/Nrf2/NF-κB signaling pathway, reducing the level of chondrocyte senescence in the KOA process.
Authors
- Zeling Huang (ORCID: https://orcid.org/0000-0002-2014-9844)
- Chaofeng Zhang (ORCID: https://orcid.org/0000-0002-1265-8681)
- Peimin Wang (ORCID: https://orcid.org/0000-0003-1870-4578)
- Yujiang Liu (ORCID: https://orcid.org/0000-0002-9631-1123)
- Zaishi Zhu
- Xiaoqing Shi (ORCID: https://orcid.org/0000-0002-3675-7326)
- Lishi Jie (ORCID: https://orcid.org/0000-0003-4158-1844)
- Bo Xu
- Yuwei Li
Institutions
- Nanjing University of Chinese Medicine (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Jiangsu Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.jep.2024.119165
- Citations
- 4
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.96