Exploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A
Our findings indicate that RBCs can serve as effective vehicle for the delivery of FVIII-derived peptides to antigen-presenting cells. The successful display of T-cell epitopes on antigen-presenting cell using ex vivo-loaded RBC may be potentially utilized to modulate pathogenic immune responses such as observed in a subset of patients with hemophilia A.
Authors
- Sébastien Lacroix‐Desmazes (ORCID: https://orcid.org/0000-0001-5625-8447)
- Floris P. J. van Alphen
- Eelke Brandsma (ORCID: https://orcid.org/0000-0001-7352-9499)
- Robin van Bruggen (ORCID: https://orcid.org/0000-0002-1676-0720)
- Maartje van den Biggelaar (ORCID: https://orcid.org/0000-0001-6970-5496)
- Mariarosaria Miranda
- Jan Voorberg (ORCID: https://orcid.org/0000-0003-4585-2621)
- Karin Fijnvandraat (ORCID: https://orcid.org/0000-0003-0904-4360)
- Lotte Robben
- Helena Van Dender
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sanquin (NL)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.jtha.2024.11.012
- Citations
- 3
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- European Commission
- Ministerie van Volksgezondheid, Welzijn en Sport
- FP7 People: Marie-Curie Actions