The role of morphological adaptability in <i>Vibrio cholerae</i> ’s motility
This study highlights the enhanced motility of filamentous <i>Vibrio cholerae</i> in viscous environments, an adaptation that may provide a survival advantage in the human gastrointestinal tract. By demonstrating increased reversal behavior at mucin interfaces, filamentous <i>V. cholerae</i> cells exhibit a superior ability to penetrate the mucus layer, which is crucial for effective colonization and infection. Filamentous cells in bile-supplemented media further underscores their potential role in disease pathogenesis. These findings offer critical insights into the morphological flexibility of <i>V. cholerae</i> and its potential implications for infection dynamics, paving the way for more effective strategies in managing and preventing cholera outbreaks.
Authors
- Jun Xu (ORCID: https://orcid.org/0000-0002-1503-5623)
- Ana A. Weil (ORCID: https://orcid.org/0000-0002-6170-4306)
- Tetsu Yamashiro (ORCID: https://orcid.org/0000-0002-8458-3287)
- Susan M. Markiewicz (ORCID: https://orcid.org/0009-0002-9695-664X)
- Toshio Kodama (ORCID: https://orcid.org/0000-0002-6511-7301)
- Marzia Sultana (ORCID: https://orcid.org/0000-0002-0862-6919)
- Keigo Abe
- Denise Chac (ORCID: https://orcid.org/0000-0002-4183-3899)
- H. Matsunami (ORCID: https://orcid.org/0000-0001-5814-3766)
- Munirul Alam (ORCID: https://orcid.org/0000-0001-9157-5560)
- Shuichi Nakamura (ORCID: https://orcid.org/0000-0003-3972-7779)
- Erika Kuba
- Shiyu Tsunoda
Institutions
- Okinawa Institute of Science and Technology Graduate University (JP)
- University of Washington (US)
- Tohoku University (JP)
- International Centre for Diarrhoeal Disease Research (BD)
- University of the Ryukyus (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- mBio
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1128/mbio.02469-24
- Citations
- 3
- Primary Topic
- Vibrio bacteria research studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Okinawa Institute of Science and Technology Graduate University
- International Centre for Diarrhoeal Disease Research, Bangladesh
- Japan Society for the Promotion of Science
- National Institute of Allergy and Infectious Diseases