Medulloblastoma therapy: Consensus treatment recommendations from SIOP-Europe and the European Reference Network
<h2>Abstract</h2> The treatment of medulloblastoma has evolved considerably over the last 10 years. Treatment intensity is now stratified within clinical trials, using risk-associated clinical features and molecular biomarkers, aimed at maximising cure rates whilst minimising long-term disease and therapy-associated side-effects. In Europe, we have developed a long-term strategy of using randomised trials to test stratified treatments across all medulloblastoma disease demographics, and to investigate further stratification using biological analysis of the samples collected. Importantly, care must be taken not to adopt experimental arms from trial protocols into routine practice, prior to trials' results being available. Moreover, there are time periods when trials are not open to recruitment for all the various risk-groups. These guidelines, developed under the auspices of SIOP-Europe and the European Reference Network for Paediatric Oncology, ERN PaedCan, review recent and current trials, alongside the literature, to provide evidence-based guidance for the contemporary therapy of medulloblastoma.
Authors
- Christelle Dufour (ORCID: https://orcid.org/0000-0001-5993-8077)
- Stefan Rutkowski (ORCID: https://orcid.org/0000-0002-5446-9571)
- Sandra Jacobs (ORCID: https://orcid.org/0000-0002-6192-6910)
- Shivaram Avula (ORCID: https://orcid.org/0000-0003-1742-7206)
- Barry Pizer (ORCID: https://orcid.org/0000-0003-4945-6386)
- Abhijit Joshi (ORCID: https://orcid.org/0000-0002-0723-2141)
- Laeticia Padovani
- Giovanni Morana (ORCID: https://orcid.org/0000-0001-8707-5969)
- Nicolás André (ORCID: https://orcid.org/0000-0002-6786-4968)
- Maria Kourti (ORCID: https://orcid.org/0000-0001-5566-9295)
- François Doz (ORCID: https://orcid.org/0000-0001-9286-4831)
- Simon Bailey (ORCID: https://orcid.org/0000-0001-9348-5497)
- Steven C. Clifford (ORCID: https://orcid.org/0000-0003-4893-2184)
- Kristian Aquilina (ORCID: https://orcid.org/0000-0001-7015-5196)
- Sabina Vennarini (ORCID: https://orcid.org/0000-0002-8712-8781)
- Maura Massimino (ORCID: https://orcid.org/0000-0002-5506-2001)
- Torsten Pietsch (ORCID: https://orcid.org/0000-0002-9252-8923)
- Ulrich W. Thomale
Institutions
- University of Liverpool (GB)
- Universität Hamburg (DE)
- Université Paris Cité (FR)
- Aristotle University of Thessaloniki (GR)
- Aix-Marseille Université (FR)
- Great Ormond Street Hospital (GB)
- Royal Victoria Infirmary (GB)
- Institut Gustave Roussy (FR)
- Humboldt-Universität zu Berlin (DE)
- Assistance Publique Hôpitaux de Marseille (FR)
- Alder Hey Children's NHS Foundation Trust (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- Ippokrateio General Hospital of Thessaloniki (GR)
- Great North Children's Hospital (GB)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Hôpital de la Timone (FR)
- Life & Brain (Germany) (DE)
- Hippocration General Hospital (GR)
- University College London (GB)
- University of Turin (IT)
- Institut Curie (FR)
- Newcastle University (GB)
- KU Leuven (BE)
Publication Details
- Journal
- EJC Paediatric Oncology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.ejcped.2024.100205
- Citations
- 14
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.13