A Case Report of an Osteolytic Mass Hiding Behind an Undiagnosed Parathyroid Adenoma

Hyperparathyroidism is a common endocrinopathy classified into three subtypes: primary, secondary, and tertiary. One of the rare symptoms that patients with hyperparathyroidism present is the formation of osteolytic lesions of the jaws. Brown tumors are rare skeletal osteolytic masses of a poorly understood etiology. These tumors are usually caused by a mutation in the CDC73 gene, a tumor suppressor protein gene that translates to parafibromin. Treatment has been reported to range from a conservative parathyroidectomy to resection and reconstruction. We present a case of a female who presented with a facial disfigurement for four months that was hidden under the effect of a parathyroid adenoma. Our aim is to guide the surgeon in the proper detailed management of osteolytic lesions of jaws that are related to parathyroid hyperfunction.

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Publication Details

Journal
Cureus
Published
2024-11-29
DOI
https://doi.org/10.7759/cureus.74762
Primary Topic
Parathyroid Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

A Case Report of an Osteolytic Mass Hiding Behind an Undiagnosed Parathyroid Adenoma

Zaid R. Alzoubi, Mohammed S. Al Olaimat, Fahad S Al Qooz, Elham M Alsharaiah et al.
Cureus
Parathyroid Disorders and Treatments
article

A Case Report of an Osteolytic Mass Hiding Behind an Undiagnosed Parathyroid Adenoma

Zaid R. Alzoubi, Mohammed S. Al Olaimat, Fahad S Al Qooz, Elham M Alsharaiah, Abdulkarim M. Alqahtani
article en

Abstract

Hyperparathyroidism is a common endocrinopathy classified into three subtypes: primary, secondary, and tertiary. One of the rare symptoms that patients with hyperparathyroidism present is the formation of osteolytic lesions of the jaws. Brown tumors are rare skeletal osteolytic masses of a poorly understood etiology. These tumors are usually caused by a mutation in the CDC73 gene, a tumor suppressor protein gene that translates to parafibromin. Treatment has been reported to range from a conservative parathyroidectomy to resection and reconstruction. We present a case of a female who presented with a facial disfigurement for four months that was hidden under the effect of a parathyroid adenoma. Our aim is to guide the surgeon in the proper detailed management of osteolytic lesions of jaws that are related to parathyroid hyperfunction.

CureusVol. 16(11)
King Hussein Medical Center (JO)
Openalex Percentile: Top 69%
Parathyroid Disorders and Treatments
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