Importance of individual residues in hydrophobic patch PLVIVGL (1481-1487) in FV-Short for synergistic TFPIα cofactor activity with protein S, an alanine-scanning study: AlphaFold-mediated prediction of FV-Short/TFPIα/protein S trimolecular complex s
Individual residues (V1483, I1484, G1486, and L1487) in the hydrophobic patch are demonstrated to be important for the synergistic TFPIα-cofactor activity and for the assembly of a trimolecular FXa-inhibitory complex.
Authors
- Björn Dahlbäck (ORCID: https://orcid.org/0000-0003-1546-0328)
- Sinh Tran (ORCID: https://orcid.org/0000-0002-1259-0672)
- Piotr Drączkowski (ORCID: https://orcid.org/0000-0002-9408-2670)
Institutions
- Stockholm University (SE)
- Malmö University (SE)
- Lund University (SE)
- Science for Life Laboratory (SE)
- Skåne University Hospital (SE)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.jtha.2024.11.013
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hjärt-Lungfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Science for Life Laboratory