Assessment of heart rate circadianity alterations in patients with depression using a wearable device
The aim of this study is to assess whether the possible loss of circadian rhythm, a modulator of heart rate, is associated with the severity of depression. For that, Cosinor fitting method was applied to heart rate data of 203 patients with major depressive disorder, recorded continuously over 18 months by a wearable device. Results revealed that the amplitude derived from the Cosinor fit is significantly lower in patients with severe depression, implying a loss in circadian rhythmicity when depression is severe.
Authors
- Matthew H. Hotopf (ORCID: https://orcid.org/0000-0002-3980-4466)
- Sara Siddi (ORCID: https://orcid.org/0000-0002-1494-9028)
- Srinivasan Vairavan (ORCID: https://orcid.org/0000-0001-7975-8436)
- Josep María Haro (ORCID: https://orcid.org/0000-0002-3984-277X)
- Alba Martín Yebra
- S.V. Juno Bella Gracia
- Faith Matcham (ORCID: https://orcid.org/0000-0002-4055-904X)
- Brenda W.J.H. Penninx (ORCID: https://orcid.org/0000-0001-7779-9672)
- Richard Dobson (ORCID: https://orcid.org/0000-0003-4224-9245)
- Vaibhav A. Narayan (ORCID: https://orcid.org/0000-0001-6092-5150)
- Femke Lamers (ORCID: https://orcid.org/0000-0003-4344-5766)
- Nicholas Cummins (ORCID: https://orcid.org/0000-0002-1178-917X)
- Raquel Bailón (ORCID: https://orcid.org/0000-0003-1272-0550)
Institutions
- Janssen (Belgium) (BE)
- University of Sussex (GB)
- King's College London (GB)
- Universidad de Zaragoza (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Parc Sanitari Sant Joan de Déu (ES)
Publication Details
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1109/esgco63003.2024.10767058
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gobierno de Aragón
- Innovative Medicines Initiative
- Medical Research Council