Assessment of QT variability in Parkinson’s Disease and REM Sleep Behaviour Disorder during REM phase

QT interval variability (QTV) is a marker of ventricular repolarization variability, frequently associated with sympathetic outflow and cardiovascular risk. This study explores QTV in drug-naϊve ten Parkison’s disease (PD), ten PD with Rapid Eye Movement (REM) Sleep Behavior Disorder (PD-RBD) subjects, and ten control (CG) participants. Five minutes of ECG data from polysomnographic recordings during REM sleep were used for analysis. To assess QTV, both time domain and frequency domain indexes were calculated. The results indicated higher QTV in PD groups compared to both CG and RBDpd, suggesting significant cardiac autonomic dysregulation in PD patients.

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Published
2024-10-23
DOI
https://doi.org/10.1109/esgco63003.2024.10767027
Primary Topic
Conducting polymers and applications
Type
article
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Assessment of QT variability in Parkinson’s Disease and REM Sleep Behaviour Disorder during REM phase

Monica Puligheddu, Laura Giorgetti, Francesco Calizzano, Danilo Pani et al.
Conducting polymers and applications
article

Assessment of QT variability in Parkinson’s Disease and REM Sleep Behaviour Disorder during REM phase

Monica Puligheddu, Laura Giorgetti, Francesco Calizzano, Danilo Pani, Francesco Famà, Pietro Mattioli, Nicla Mandas, Michela Figorilli, Parisa Sattar, Dario Arnaldi, Pablo Laguna, Elisa Casaglia, Giulia Baldazzi, Raquel Bailón
article en

Abstract

QT interval variability (QTV) is a marker of ventricular repolarization variability, frequently associated with sympathetic outflow and cardiovascular risk. This study explores QTV in drug-naϊve ten Parkison’s disease (PD), ten PD with Rapid Eye Movement (REM) Sleep Behavior Disorder (PD-RBD) subjects, and ten control (CG) participants. Five minutes of ECG data from polysomnographic recordings during REM sleep were used for analysis. To assess QTV, both time domain and frequency domain indexes were calculated. The results indicated higher QTV in PD groups compared to both CG and RBDpd, suggesting significant cardiac autonomic dysregulation in PD patients.

University of Cagliari (IT), Universidad de Zaragoza (ES), Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES), Azienda Ospedaliero-Universitaria Cagliari (IT), Ospedale Policlinico San Martino (IT), University of Genoa (IT)
Openalex Percentile: Top 83%
Conducting polymers and applications
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