A Case of Drug-Induced Lupus in Crohn’s Disease During Infliximab Therapy

A 46-year-old man with a known case of Crohn's disease, which developed in August 2010, had been in remission since then with infliximab treatment. However, in November 2023, he developed photosensitivity, followed by joint pain and general fatigue in December. Blood tests revealed positive antinuclear antibodies, leading to a diagnosis of drug-induced lupus. After switching from infliximab to vedolizumab, his symptoms improved, and antinuclear antibodies became negative. We present a case of Crohn's disease in which drug-induced lupus developed after approximately 14 years of infliximab treatment. Cases of drug-induced lupus developing from long-term administration of tumor necrosis factor alpha (TNFα) inhibitors are rare, so we report this case with a literature review.