Replacing dietary carbohydrate with protein and fat improves lipoprotein subclass profile and liver fat in type 2 diabetes independent of body weight: evidence from 2 randomized controlled trials
Replacing dietary carbohydrate with protein and fat improves dyslipidemia in T2D independently of changes in body weight, by inducing an atheroprotective shift in the lipoprotein particle profile possibly facilitated by reduced IHTG accumulation. These trials were registered at clinicaltrials.gov as NCT02764021 (https://clinicaltrials.gov/study/NCT02764021?term=NCT02764021&rank=1) and NCT03814694 (https://clinicaltrials.gov/study/NCT03814694?term=NCT03814694&rank=1).
Authors
- Faidon Magkos (ORCID: https://orcid.org/0000-0002-1312-7364)
- Steen B. Haugaard (ORCID: https://orcid.org/0000-0002-6827-7036)
- Thure Krarup (ORCID: https://orcid.org/0000-0002-9152-0583)
- Elizaveta Hansen
- Amirsalar Samkani (ORCID: https://orcid.org/0000-0002-2742-3893)
- Jan Frystyk (ORCID: https://orcid.org/0000-0002-5379-0961)
- Philip Weber
- Sten Madsbad (ORCID: https://orcid.org/0000-0002-5017-1815)
- Mads J. Skytte (ORCID: https://orcid.org/0000-0001-6607-2064)
- Henrik S. Thomsen (ORCID: https://orcid.org/0000-0002-2409-9725)
- Rosemary L. Walzem (ORCID: https://orcid.org/0000-0002-9913-7810)
- Mogens Fenger (ORCID: https://orcid.org/0000-0001-8952-8394)
- Jens J. Holst (ORCID: https://orcid.org/0000-0001-6853-3805)
- Mads N. Thomsen (ORCID: https://orcid.org/0000-0002-3821-320X)
Institutions
- University of Copenhagen (DK)
- Novo Nordisk Foundation (DK)
- Odense University Hospital (DK)
- Herlev Hospital (DK)
- Bispebjerg Hospital (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
- Texas A&M University (US)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.ajcnut.2024.11.030
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Texas AgriLife Research
- Aarhus Universitet
- Gentofte Hospital
- Mejeribrugets ForskningsFond
- Bispebjerg Hospital