Inter- and intra-tumoral heterogeneity on [68Ga]Ga-DOTA-TATE/[68Ga]Ga-DOTA-TOC PET/CT predicts response to [177Lu]Lu-DOTA-TATE PRRT in neuroendocrine tumor patients
Our exploratory analysis provides preliminary results showing that imaging indices of inter- and intra-tumor heterogeneity from pretreatment PET/CT images may potentially predict treatment efficacy in NET patients undergoing [<sup>177</sup>Lu]Lu-DOTA-TATE therapy. However, prospective evaluation in a larger cohort is needed to further assess whether a comprehensive characterization of tumor heterogeneity within a patient can help guide treatment decisions.
Authors
- Ahmad Shariftabrizi (ORCID: https://orcid.org/0000-0003-2397-6914)
- Joseph S. Dillon (ORCID: https://orcid.org/0000-0002-4002-1418)
- Stephen A. Graves (ORCID: https://orcid.org/0000-0003-2732-3064)
- Janet H. Pollard (ORCID: https://orcid.org/0000-0003-3081-6548)
- Sanchay Jain (ORCID: https://orcid.org/0000-0002-6598-8035)
- Sarah L. Mott (ORCID: https://orcid.org/0000-0001-9381-2080)
- Yusuf Menda (ORCID: https://orcid.org/0000-0001-7551-2789)
- Bradley T. Loeffler (ORCID: https://orcid.org/0009-0001-1742-3048)
- Ayca Dundar (ORCID: https://orcid.org/0000-0002-3128-6801)
- Camila Gadens Zamboni (ORCID: https://orcid.org/0000-0002-2365-7908)
- Michael M. Graham (ORCID: https://orcid.org/0000-0002-6374-4766)
- Marc Kruzer
Institutions
- University of Iowa (US)
- University of Iowa Health Care (US)
- RHAMM Technologies (United States) (US)
- University of Iowa Holden Comprehensive Cancer Center
Publication Details
- Journal
- EJNMMI Reports
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s41824-024-00227-3
- Citations
- 6
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 2.32