Maternal polycystic ovary syndrome and Offspring’s Risk of Cardiovascular diseases in Childhood and Young Adulthood
Children born to mothers with polycystic ovary syndrome have a higher prevalence of cardiovascular risk factors and of subclinical cardiovascular disease, but the association between maternal polycystic ovary syndrome and cardiovascular disease in offspring is unclear. We conduct a register-based cohort study of 6 839 703 live singleton births from Denmark (1973-2016) and Sweden (1973-2014) and follow them for up to 48 years. Using Cox regression models, we find that offspring of mothers with polycystic ovary syndrome have a higher risk of overall cardiovascular diseases and of its specific subtypes, independently of comorbidities related to polycystic ovary syndrome. Cousin analyzes suggest that familial confounding does not explain our results. If our findings are replicated by future studies, children of women with polycystic ovary syndrome may benefit from early cardiovascular prevention efforts.
Authors
- Henrik Toft Sørensen (ORCID: https://orcid.org/0000-0003-4299-7040)
- Maohua Miao (ORCID: https://orcid.org/0000-0002-8120-355X)
- Mika Gissler (ORCID: https://orcid.org/0000-0001-8254-7525)
- Krisztina D. László (ORCID: https://orcid.org/0000-0002-4695-477X)
- Nathalie Roos (ORCID: https://orcid.org/0000-0001-9752-2355)
- Imre Janszky (ORCID: https://orcid.org/0000-0001-7420-5461)
- Jiong Li (ORCID: https://orcid.org/0000-0003-1125-026X)
- Ziliang Wang (ORCID: https://orcid.org/0000-0003-4375-4964)
- Yuan Wei (ORCID: https://orcid.org/0000-0003-3387-7549)
- Anna-Karin Wikström
- Yang Fen (ORCID: https://orcid.org/0000-0002-8181-9557)
Institutions
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Norwegian University of Science and Technology (NO)
- Aarhus University Hospital (DK)
- Karolinska Institutet (SE)
- Finnish Institute for Health and Welfare (FI)
- Stockholm Health Care Services (SE)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1038/s41467-024-54795-w
- Citations
- 4
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Hjärt-Lungfonden
- Karolinska Institutet
- Novo Nordisk
- China Scholarship Council
- Danmarks Frie Forskningsfond
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Novo Nordisk Fonden
- National Key Research and Development Program of China