Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs
TLR agonists promote acute airway inflammation and induce airway obstruction and hyperresponsiveness in guinea pigs. The severity of these effects varies depending on the specific agonists used. Notably, dexamethasone reversed pulmonary functional changes and mitigated bronchial inflammation caused by the combined treatment of P/I. However, it had no impact on the expression of inflammatory mediators.
Authors
- Mikael Adner (ORCID: https://orcid.org/0000-0003-1634-4759)
- Yujiao Xiang
- Jesper Säfholm (ORCID: https://orcid.org/0000-0003-1922-8104)
- Jielu Liu
- Gunnar Nilsson (ORCID: https://orcid.org/0000-0001-7811-7602)
- Mu Nie (ORCID: https://orcid.org/0009-0000-9429-5783)
Institutions
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s12931-024-03050-3
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Hjärt-Lungfonden
- Karolinska Institutet
- Magnus Bergvalls Stiftelse