Fecal microbiota transplantation validates the importance of gut microbiota in an ApoE−/− mouse model of chronic apical periodontitis-induced atherosclerosis
The study confirms the role of gut microbiota disruption in CAP-mediated atherosclerosis development, independent of serum lipid or TMAO levels. Alterations in gut microbiota composition, particularly increased Firmicutes to Bacteroidetes ratio and specific bacterial families, were associated with atherosclerosis severity. These findings highlight the intricate interplay between gut microbiota and cardiovascular health in the context of CAP.
Authors
- Beibei Lu (ORCID: https://orcid.org/0000-0002-7588-1979)
- Huaxiang Lei (ORCID: https://orcid.org/0000-0002-7261-7128)
- Zhiyu Cai (ORCID: https://orcid.org/0000-0002-5227-851X)
- Ren Zhang (ORCID: https://orcid.org/0000-0002-8437-3562)
- Guowu Gan (ORCID: https://orcid.org/0000-0002-3189-9915)
- Shuai Chen (ORCID: https://orcid.org/0000-0002-6812-1525)
- Yu Zeng (ORCID: https://orcid.org/0000-0002-1272-2209)
- Xiaojing Huang (ORCID: https://orcid.org/0000-0002-1590-7479)
- Yufang Luo
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s12903-024-05230-5
- Citations
- 10
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Natural Science Foundation of China
- Fujian Provincial Health Technology Project