Effect of timing of norepinephrine administration on prognosis of patients with septic shock: A prospective cohort study
Norepinephrine initiation ≤1 h is associated with lower 28-day mortality in patients with septic shock. Early norepinephrine administration is also associated with a shorter time to achieve MAP ≥65 mmHg, lower 24-hour intravenous fluids volume, and higher 6-hour Lac clearance rate. Being male, time to achieve MAP ≥65 mmHg, and norepinephrine initiation >1 h are independent risk factors for 28-day mortality.<b>Trial registration</b> Chinese Clinical Trial Registry Identifier: ChiCTR2100044071.
Authors
- Yuting Li (ORCID: https://orcid.org/0009-0008-3848-8589)
- Deyou Zhang
- Dong Zhang (ORCID: https://orcid.org/0000-0002-3404-5173)
- Hongxiang Li (ORCID: https://orcid.org/0000-0002-1399-8039)
- Youquan Wang (ORCID: https://orcid.org/0000-0001-5437-7960)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Journal of Intensive Medicine
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.jointm.2024.10.002
- Citations
- 3
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Ministry of Science and Technology of the People's Republic of China
- China Primary Health Care Foundation
- Wu Jieping Medical Foundation