Cutaneous phosphorylated-synuclein: an early diagnostic biomarker for pure autonomic failure
Cutaneous p-syn was abundant in PAF, a predominantly peripheral alpha-synucleinopathy. It is a promising biomarker to help distinguish between PAF, MSA and non-synucleinopathy-related autonomic failure to aid early diagnosis and recruitment to future clinical trials. P-syn deposition on autonomic nerves may impair control of total peripheral resistance giving rise to symptomatic orthostatic hypotension.
Authors
- Giuseppe Caporaso (ORCID: https://orcid.org/0000-0001-5822-7505)
- Vincenzo Provitera (ORCID: https://orcid.org/0000-0003-1230-942X)
- Ilaria Borreca
- Maria Nolano (ORCID: https://orcid.org/0000-0002-4849-1318)
- Annamaria Stancanelli (ORCID: https://orcid.org/0000-0003-1847-1890)
- Michael Peter Lunn (ORCID: https://orcid.org/0000-0003-3174-6027)
- Valeria Iodice
- Shiwen Koay (ORCID: https://orcid.org/0000-0002-0860-9211)
- Ekawat Vichayanrat (ORCID: https://orcid.org/0000-0001-6183-0997)
- Fernanda Valério (ORCID: https://orcid.org/0000-0001-5248-7314)
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Istituti Clinici Scientifici Maugeri (IT)
- MRC Prion Unit (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1136/jnnp-2024-334615
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Guarantors of Brain
- Ministero della Salute