Epilepsy is associated with the accelerated aging of brain activity in sleep
Epilepsy is associated with accelerated brain aging. Higher brain age indices are associated with poorer cognition and more severe epilepsy, specifically generalizability and higher seizure burden. These findings strengthen the use of the sleep-derived, electroencephalography-based BAI as a biomarker for cognitive dysfunction in epilepsy.
Authors
- Rhoda Au (ORCID: https://orcid.org/0000-0001-7742-4491)
- Michael Brandon Westover (ORCID: https://orcid.org/0000-0003-4803-312X)
- Chol Shin (ORCID: https://orcid.org/0000-0002-2928-8576)
- Sydney S. Cash (ORCID: https://orcid.org/0000-0002-4557-6391)
- Robert J. Thomas (ORCID: https://orcid.org/0000-0003-3216-7203)
- Luis Gustavo Porto Paixão (ORCID: https://orcid.org/0000-0001-6243-3264)
- Mike Westmeijer (ORCID: https://orcid.org/0000-0002-2896-9994)
- Haoqi Sun (ORCID: https://orcid.org/0000-0002-5041-8312)
- Peter Hadar (ORCID: https://orcid.org/0000-0002-1681-4717)
- Pierrick J. Arnal
- Ryan A. Tesh (ORCID: https://orcid.org/0000-0002-6154-6248)
- Soriul Kim (ORCID: https://orcid.org/0000-0002-6161-1636)
- Madalena Da Silva Cardoso (ORCID: https://orcid.org/0000-0002-5792-5288)
- Jing Jin (ORCID: https://orcid.org/0000-0002-6133-5491)
- Erik‐Jan Meulenbrugge (ORCID: https://orcid.org/0000-0002-1580-4170)
Institutions
- Boston University (US)
- Beth Israel Deaconess Medical Center (US)
- Utrecht University (NL)
- Korea University (KR)
- NYU Langone Health (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fphys.2024.1458592
- Citations
- 6
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.31