Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate
Female gender, recessive mutation in ABCB1 rs1128503, and a range of MTX concentration may be risk factors for increased susceptibility to DILI. Conversely, the *1b/*1b and *1b/*15 mutations in <i>SLCO1B1</i> may have a protective effect against DILI. The proposed predictive model facilitates early individual risk assessment, enabling the implementation of proactive prevention strategies.
Authors
- Rui Ma (ORCID: https://orcid.org/0000-0002-6441-6297)
- Mouze Liu
- Hualin Cai (ORCID: https://orcid.org/0000-0002-5472-0236)
- Ting Cao (ORCID: https://orcid.org/0000-0001-9192-6981)
- Chenquan Lin
- Shimeng Jiao
- Bikui Zhang (ORCID: https://orcid.org/0000-0001-7148-7926)
- Xiao Zeng (ORCID: https://orcid.org/0000-0003-1187-0645)
- Yifang He
- Hui Chen (ORCID: https://orcid.org/0000-0002-7622-8867)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fphar.2024.1423214
- Citations
- 3
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Central South University
- Chinese Pharmaceutical Association
- Natural Science Foundation of Hunan Province
- Xiangya Hospital, Central South University
- Fundamental Research Funds for the Central Universities