Acute toxicity and biodistribution assessment of quantum dots conjugated to lectins from <i>Schinus terebinthifolia</i> leaves (SteLL) and <i>Punica granatum</i> sarcotesta (PgTeL)
This work reports the <i>in vivo</i> investigation of telluride cadmium quantum dots (CdTe QDs) conjugated to plant lectins from <i>Schinus terebinthifolia</i> (SteLL) and <i>Punica granatum</i> (PgTeL) for acute toxicity and genotoxicity in healthy mice and 24-h biodistribution in sarcoma 180-bearing animals. Acute toxicity data indicated their safety, despite some histopathological alterations. Comet assay revealed that the QDs-PgTeL group presented a higher damage index and frequency of damage than the negative control. The micronucleus test did not reveal a genotoxic effect. The 24-h biodistribution study showed a major uptake of cadmium by the liver, spleen, and kidneys. A greater accumulation of cadmium was found in tumors of the QDs-SteLL group. In conclusion, the biodistribution study showed no influence of the studied lectins in the absorption of QDs by different organs and that the conjugation of SteLL resulted in increased targeting of QDs to sarcoma 180 cells, suggesting a potential theranostic application in cancer.
Authors
- Leydianne Leite de Siqueira Patriota (ORCID: https://orcid.org/0000-0003-4600-6136)
- Adriana Fontes (ORCID: https://orcid.org/0000-0003-4675-2163)
- Robson Raion de Vasconcelos Alves (ORCID: https://orcid.org/0000-0002-7539-0491)
- Alisson Macário de Oliveira (ORCID: https://orcid.org/0000-0003-4152-150X)
- Raquel Cordeiro de Oliveira
- Paulo E. Cabral Filho (ORCID: https://orcid.org/0000-0002-1628-7769)
- Abdênego Rodrigues da Silva (ORCID: https://orcid.org/0000-0001-7327-828X)
- Talita Giselly dos Santos Souza (ORCID: https://orcid.org/0000-0001-5254-3056)
- Elvis Joacir de França (ORCID: https://orcid.org/0000-0002-0027-2028)
- M. L. Oliveira (ORCID: https://orcid.org/0000-0001-6410-4157)
- Thiago Henrique Napoleão (ORCID: https://orcid.org/0000-0002-0065-2602)
- Fernanda das Chagas Ângelo Mendes Tenório (ORCID: https://orcid.org/0000-0002-8255-356X)
- Patrícia Maria Guedes Paiva (ORCID: https://orcid.org/0000-0003-3467-708X)
- Matheus Cavalcanti de Barros (ORCID: https://orcid.org/0000-0002-8769-0221)
Institutions
- Universidade Federal de Pernambuco (BR)
- Centro de Tecnologias Estratégicas do Nordeste (BR)
Publication Details
- Journal
- Drug and Chemical Toxicology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1080/01480545.2024.2433074
- Primary Topic
- Quantum Dots Synthesis And Properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00