Prognostic factors associated with worse outcomes following chemoradiation therapy in patients with anal carcinoma
Our study showed that male sex, younger age, DCCI of 1 and 3, and increased tumour size were predictive of CRT failure among patients with anal SCC. Increased age, male sex, Black race, non-insured status, increased DCCI, and more aggressive tumour characteristics were associated with increased 5-year overall mortality. More importantly, patients who failed CRT had worse 5-year overall survival. Our findings support increased emphasis on intensive surveillance for these high-risk patient cohorts.
Authors
- Danielle Alexandra Dooley
- David Schaub (ORCID: https://orcid.org/0000-0002-7226-0157)
- Anjing Gong (ORCID: https://orcid.org/0000-0001-6167-1930)
- Muhammad Khurrum (ORCID: https://orcid.org/0000-0002-9960-6955)
- Valentine Nfonsam (ORCID: https://orcid.org/0000-0002-1213-8053)
- Mitch Hargis (ORCID: https://orcid.org/0000-0001-8112-052X)
- Manijeh Assar
- Joseph Gunderson (ORCID: https://orcid.org/0000-0001-6091-171X)
- Andrea Delgado Moreno (ORCID: https://orcid.org/0000-0001-9258-6309)
- José C. Cruz (ORCID: https://orcid.org/0000-0002-2923-675X)
- Alejandro Cruz
- Daniom Tecle
Institutions
- Louisiana State University (US)
- University of Arizona (US)
- New York University Langone Orthopedic Hospital (US)
Publication Details
- Journal
- Colorectal Disease
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1111/codi.17225
- Primary Topic
- Colorectal and Anal Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00