Negative response to immunotherapy in dMMR or MSI-H gastric cancer with APC and PTEN mutations: a case report
Mutations of key genes within tumor-related signaling pathways and the infiltration of CD8<sup>+</sup>T cells in the tumor microenvironment may influence the efficacy of immunotherapy for MSI-H solid tumors.
Authors
- Chuanjun Song (ORCID: https://orcid.org/0000-0001-7733-578X)
- Dadong Chen
- Jianhe Yu
- Yin Cai
- Xiumei Zhang (ORCID: https://orcid.org/0000-0002-6720-760X)
- Qun Ren (ORCID: https://orcid.org/0000-0002-3096-7701)
- Jiang Liu (ORCID: https://orcid.org/0000-0001-8873-2553)
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fonc.2024.1484802
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85