Elucidating the potential of Annona muricata L. grown in Sri Lanka to be used in developing an anticancer drug against colorectal and breast cancers
The AEAM leaves grown in Sri Lanka has significantly higher antioxidant activity as well as selective cytotoxic effects on MCF-7 and DLD-1 cancer cells compared to its PL and P counterparts. Further, the AEAM leaves induced mRNA expression of the anticancer genes p21, Bax and caspase-7, indicating its potential to be developed into an anticancer drug against breast and colorectal cancer.
Authors
- Thilini Anupama Nanayakkarawasam Mahakapuge
- Jayantha Rajapakse
- Kavindra Kumara Wijesundera (ORCID: https://orcid.org/0000-0002-3475-2564)
- Madhavi Priyanka Paranagama (ORCID: https://orcid.org/0000-0001-9606-9114)
- Onela Canith Pathirana
- Abeykoon Mudiyanselage Anuththara U Abeykoon
Institutions
- University of Peradeniya (LK)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12906-024-04712-x
- Citations
- 4
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- University of Peradeniya
- Faculty of Veterinary Medicine and Animal Science, Poznań University of Life Sciences