A rat model establishment of bronchopulmonary dysplasia-related lung & brain injury within 28 days after birth
The BPD-rats model was established successfully. Lung injury in the BPD group evident across the bronchi to the alveoli and pulmonary vessels, which was associated with deteriorated lung function at postnatal day 14. Concurrently, brain injury extended from the cerebral cortex to the hippocampus, which was associated with impaired performance in orientation navigation and spatial probe tests at postnatal day 28.
Authors
- Meicen Zhou (ORCID: https://orcid.org/0009-0006-2389-8302)
- Hua Wang (ORCID: https://orcid.org/0000-0002-2605-5697)
- Xin Lin (ORCID: https://orcid.org/0000-0002-7491-8928)
Institutions
- Fujian Medical University (CN)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12868-024-00912-w
- Citations
- 5
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Sichuan University