A novel pan-epitope based nanovaccine self-assembled with CpG enhances immune responses against flavivirus
The self-assembled candidate nanovaccine TBT-CpG NaVs effectively activates BMDCs and triggers a targeted immune response, providing antiviral effects against DENV and ZIKV. This vaccine demonstrates good immunogenicity and safety, establishing a promising foundation and a new strategy for the development of safe and effective vaccines.
Authors
- Jintao Li (ORCID: https://orcid.org/0000-0003-3637-2386)
- Xiaoyan Ding (ORCID: https://orcid.org/0000-0003-0484-2750)
- Jiuxiang He
- Minyue Qiu (ORCID: https://orcid.org/0000-0002-7718-3111)
- Minchi Liu
- Hongxia Guo
- Jing Zhao (ORCID: https://orcid.org/0000-0002-0345-867X)
- Jie Zeng (ORCID: https://orcid.org/0000-0003-0495-5093)
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Wen Xiao (ORCID: https://orcid.org/0000-0001-6001-7523)
- Yuxin Zhou
- Hua Dong
Institutions
- Army Medical University (CN)
- Ludwig-Maximilians-Universität München (DE)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12951-024-03031-0
- Citations
- 9
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 4.89
Funders
- Army Medical University