High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study
This study supports the concept that the specificity of autoreactive IgG in MS is highly heterogeneous. Despite that we suggest that the combination of several B-cell epitopes could be employed as reliable and simple test for MS diagnostics.
Authors
- Leyla A. Ovchinnikova (ORCID: https://orcid.org/0000-0002-3086-0728)
- Elena N. Ilina (ORCID: https://orcid.org/0000-0003-0130-5079)
- Yakov A. Lomakin (ORCID: https://orcid.org/0000-0002-3514-5395)
- С. Н. Иллариошкин (ORCID: https://orcid.org/0000-0002-2704-6282)
- Ksenia M. Klimina (ORCID: https://orcid.org/0000-0002-5563-644X)
- Yury P. Rubtsov (ORCID: https://orcid.org/0000-0001-9175-3013)
- Alexander G. Gabibov (ORCID: https://orcid.org/0000-0001-8665-3288)
- Т. О. Simaniv (ORCID: https://orcid.org/0000-0001-7256-2668)
- Igor E. Eliseev (ORCID: https://orcid.org/0000-0002-3344-2513)
- Samir S. Dzhelad
- Ivanova Mv (ORCID: https://orcid.org/0000-0001-7818-2869)
- Maria Zakharova (ORCID: https://orcid.org/0009-0006-2699-7023)
Institutions
- National Research University Higher School of Economics (RU)
- Lomonosov Moscow State University (RU)
- Institute of Bioorganic Chemistry (RU)
- Research Center of Neurology (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fimmu.2024.1401156
- Citations
- 3
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Russian Science Foundation
- National Research University Higher School of Economics