Integrated immunogenomic analyses of high-grade serous ovarian cancer reveal vulnerability to combination immunotherapy
Genomic instability in HGSOC affects the tumor immune environment, and TAMs play a crucial role in modulating the immune response. Based on various datasets, we have developed a diagnostic application that uses RNA sequencing data not only to comprehensively characterize HGSOC but also to predict vulnerability and response to combination immunotherapy.
Authors
- Heidi Fiegl (ORCID: https://orcid.org/0000-0002-1236-6806)
- Christian Marth (ORCID: https://orcid.org/0000-0002-8965-9981)
- Hubert Hackl (ORCID: https://orcid.org/0000-0003-4055-3841)
- Alain G. Zeimet (ORCID: https://orcid.org/0000-0001-5306-2334)
- Pablo Monfort‐Lanzas (ORCID: https://orcid.org/0000-0003-2589-3960)
- Leonie Madersbacher
- Susanne Sprung
- Raphael Gronauer (ORCID: https://orcid.org/0009-0009-0892-2628)
- Gabriel Floriani
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fimmu.2024.1489235
- Citations
- 4
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- Oesterreichische Nationalbank
- Medizinische Universität Innsbruck
- Universität Innsbruck