Intra-tumoral lymphocyte scoring in colorectal cancer: improving prognostic utility and correlation with underlying cancer biology
I-score, in our study, was closely associated with potentially confounding biologic variables such as sex, active smoking, pTNM stage, and mutations in BRAF, and MMR genes. More precise and biologically relevant biomarkers can be achieved by using data-driven CD3<sup>+</sup>/CD8<sup>+</sup> density cutoffs and ratios, while controlling for important clinicopathologic and molecular variables in CRC. Independent validation and inclusion of other relevant immunocyte types could bring these findings closer to clinical utility in CRC.
Authors
- Cynthia L. Sears (ORCID: https://orcid.org/0000-0003-4059-1661)
- Patrick Wagner (ORCID: https://orcid.org/0000-0001-8105-653X)
- Ni Zhao (ORCID: https://orcid.org/0000-0002-7762-3949)
- Ali H. Zaidi (ORCID: https://orcid.org/0000-0002-5463-2252)
- Curtis Tilves (ORCID: https://orcid.org/0000-0003-0281-5986)
- Noel T. Mueller (ORCID: https://orcid.org/0000-0002-7412-8352)
- William A. LaFramboise (ORCID: https://orcid.org/0000-0002-6024-810X)
- Neda Dadgar (ORCID: https://orcid.org/0000-0003-3220-7148)
- Jianwu Xie
- Chelsea Knotts (ORCID: https://orcid.org/0000-0002-9727-9030)
- Justine W. Debelius (ORCID: https://orcid.org/0000-0002-8605-3546)
- Kunhong Xiao (ORCID: https://orcid.org/0000-0002-1069-1226)
- Hyun Park (ORCID: https://orcid.org/0000-0002-7825-9165)
- Louis Gil Acevedo
- Devin C. Flaherty
Institutions
- Allegheny Health Network (US)
- Cleveland Clinic (US)
- Johns Hopkins University (US)
- Karolinska Institutet (SE)
- Winchester Medical Center (US)
Publication Details
- Journal
- Frontiers in Gastroenterology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fgstr.2024.1493949
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.28