Altered gut microbiome in convalescent patients with coronavirus disease 2019

At the order level, <i>Eubacteriales</i> and <i>Bifidobacteriales</i> decreased, while <i>Bacteroidales</i> and <i>Burkholderiales</i> increased in the COVID-19 group compared to the controls. Alpha diversity also decreased in COVID-19 patients compared to controls, with imperfect recovery of the gut microbiome after seven months. The compositional change in the gut microbiome between the early and late convalescent phases was largest in the moderate and severe groups. The severity of COVID-19 was the most influential clinical variable for microbiome composition (Sum of Sqs = 0.686, <i>P</i> = 0.006), and its effect persisted even after partialling out other effects such as antibiotic use and age. Thus, our study indicates a possible interaction between respiratory viral infection and the composition of the gut microbiota community, warranting future mechanistic and prospective longitudinal studies. Additionally, we were able to detect microbiome changes in patients who were re-infected with SARS-CoV-2. Notably, the dominant bacteria in the re-infected group were <i>Lachnospiraceae</i> and <i>Faecalimonas umbilicata</i>, compared to the one-time infected group.

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Publication Details

Journal
Frontiers in Cellular and Infection Microbiology
Published
2024-11-28
DOI
https://doi.org/10.3389/fcimb.2024.1455295
Citations
2
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.47

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article

Altered gut microbiome in convalescent patients with coronavirus disease 2019

Kyoung Hwa Lee, Jen J. H. Yong, Young Goo Song, Gloria B. Choi et al.
2 citations
Frontiers in Cellular and Infection Microbiology
Gut microbiota and health
0.47
article

Altered gut microbiome in convalescent patients with coronavirus disease 2019

Kyoung Hwa Lee, Jen J. H. Yong, Young Goo Song, Gloria B. Choi, Jun Ryul Huh, Inseong Cha, Sang Hoon Han, So Hee Dho, Eun Hwa Lee, Hyunseok Oh, Wonjin Woo, Seung-Jo Yang, Jongsik Chun, Su Jin Jeong, Yeong Ouk Kim, Jae‐Phil Choi, Lark Kyun Kim, Je Hee Lee
article en
2 citations

Abstract

At the order level, <i>Eubacteriales</i> and <i>Bifidobacteriales</i> decreased, while <i>Bacteroidales</i> and <i>Burkholderiales</i> increased in the COVID-19 group compared to the controls. Alpha diversity also decreased in COVID-19 patients compared to controls, with imperfect recovery of the gut microbiome after seven months. The compositional change in the gut microbiome between the early and late convalescent phases was largest in the moderate and severe groups. The severity of COVID-19 was the most influential clinical variable for microbiome composition (Sum of Sqs = 0.686, <i>P</i> = 0.006), and its effect persisted even after partialling out other effects such as antibiotic use and age. Thus, our study indicates a possible interaction between respiratory viral infection and the composition of the gut microbiota community, warranting future mechanistic and prospective longitudinal studies. Additionally, we were able to detect microbiome changes in patients who were re-infected with SARS-CoV-2. Notably, the dominant bacteria in the re-infected group were <i>Lachnospiraceae</i> and <i>Faecalimonas umbilicata</i>, compared to the one-time infected group.

Frontiers in Cellular and Infection MicrobiologyVol. 14
Harvard University (US), Seoul National University (KR), Yonsei University (KR), Keio University (JP), Seoul Medical Center (KR), Boston VA Research Institute (US), Gangnam Severance Hospital (KR), Massachusetts Institute of Technology (US)
National Research Foundation, Yonsei University, National Research Foundation of Korea, Ministry of Science and ICT, South Korea, Yonsei University College of Medicine
Good health and well-being
Openalex Percentile: Top 34%
Gut microbiota and health
0.47
DOIOpen Access PDFOpenAlex
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