Cross‐pathway integration of cAMP signals through cGMP and calcium‐regulated phosphodiesterases in mouse striatal cholinergic interneurons
The expression pattern of specific PDE enzymes in striatal cholinergic interneurons, by integrating diverse intracellular pathways, can adjust cAMP responses bidirectionally. These properties eventually allow striatal cholinergic interneurons to dynamically regulate their overall activity and modulate acetylcholine release. Remarkably, this effect is the opposite of the cGMP-induced inhibition of cAMP signals involving PDE2A in striatal medium-sized spiny neurons, which provides important insights for the understanding of signal integration in the striatum.
Authors
- Jan Kehler (ORCID: https://orcid.org/0009-0006-6450-7005)
- Pierre Vincent (ORCID: https://orcid.org/0000-0002-8479-1908)
- Ségolène Bompierre (ORCID: https://orcid.org/0000-0003-1140-4409)
- Élia Mota (ORCID: https://orcid.org/0000-0003-4393-5781)
- Liliana Raquel Castro (ORCID: https://orcid.org/0000-0001-8902-089X)
- Yelyzaveta Byelyayeva (ORCID: https://orcid.org/0009-0002-8650-9635)
- Anna Pumo (ORCID: https://orcid.org/0009-0000-0728-864X)
- Marine Lefèvre
Institutions
- Centre National de la Recherche Scientifique (FR)
- Lundbeck (Denmark) (DK)
- Inserm (FR)
- Université de Montpellier (FR)
- Sorbonne Université (FR)
- Adaptation Biologique et Vieillissement (FR)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1111/bph.17400
- Citations
- 1
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Agence Nationale de la Recherche
- Association France Parkinson