PACAP/PAC1 regulation in cystitis rats: induction of bladder inflammation cascade leading to bladder dysfunction
The findings provide compelling evidence that the PACAP/PAC1 pathway is involved in the inflammatory and sensory changes observed in IC/BPS. By targeting this signaling pathway, we may offer a novel therapeutic approach to mitigate the symptoms of IC/BPS. This study enhances our understanding of the molecular mechanisms driving IC/BPS and opens avenues for the development of targeted treatments.
Authors
- Lin Zhu (ORCID: https://orcid.org/0000-0001-6929-9205)
- Huanrui Wang
- Kexin Xu (ORCID: https://orcid.org/0000-0003-1057-1467)
- Zehua Ding
- Qi Wang (ORCID: https://orcid.org/0000-0002-1588-9047)
- Weiyu Zhang (ORCID: https://orcid.org/0000-0002-8928-6636)
- Dongyu Su
- Hanwei Ke (ORCID: https://orcid.org/0000-0003-2399-4995)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking University People's Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fimmu.2024.1413078
- Citations
- 2
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University People's Hospital