Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease
Our study provides evidence for the heterogeneous alterations in brain structural network across different stages of cognitive impairment in CSVD. The disconnection of brain structural network at NCI stage is mainly the loss of redundant connections. The decline of Eg is the vital factor for cognitive impairment at MCI stage. The decline of all network characteristics is the prominent manifestation at VaD stage. Throughout the cognitive decline process in CSVD, there are trade-offs among the brain network wiring cost, integration, and segregation.
Authors
- Dinggang G. Shen (ORCID: https://orcid.org/0000-0002-7934-5698)
- Yage Qiu (ORCID: https://orcid.org/0000-0002-5829-9434)
- Xu Han (ORCID: https://orcid.org/0000-0002-4289-1636)
- Mianxin Liu (ORCID: https://orcid.org/0000-0001-5171-778X)
- Yuewei Chen (ORCID: https://orcid.org/0000-0001-8681-5734)
- Yao Wang (ORCID: https://orcid.org/0000-0001-5433-7360)
- Yan Zhou (ORCID: https://orcid.org/0009-0009-2316-8168)
- Qun Xu (ORCID: https://orcid.org/0000-0002-5956-2927)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- ShanghaiTech University (CN)
- Beijing Academy of Artificial Intelligence (CN)
- Shanghai Artificial Intelligence Laboratory (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fnagi.2024.1465181
- Citations
- 2
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.49
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Shenkang Hospital Development Center
- Renji Hospital